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KMID : 0370220230670060372
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Yakhak Hoeji
2023 Volume.67 No. 6 p.372 ~ p.377
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Ovarian Absorption and Systemic Bioavailability Study of Paeoniflorin Solubilized with L-Lysine
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Hwang Ye-Jin
Kim Ah-Rum
Kim Hyeon-Woo
Kang Jae-Seon
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Abstract
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Menopause refers to the period in a woman’s life when ovarian function declines, leading to a cessation ofovulation and a significant hormonal shift. Commonly associated symptoms include facial flushing, sleep disturbances,fatigue, and depression. These symptoms are typically treated with hormone therapy, although there is concern about theincreased risk of endometrial cancer, cardiovascular disease, and breast cancer associated with excessive estrogen use. Thishas led to a growing interest in natural remedies as an alternative approach. Paeoniflorin is a pharmacologically activecompound found in Paeonia lactiflora, one of the major components of this plant. Paeonia lactiflora has been traditionallyused to treat women’s health issues, but there is currently insufficient research in this area compared to its historical use.
Moreover, there is a lack of studies on ovarian absorption rates, prompting the present study. In this research, paeoniflorinwas solubilized using L-Lysine, and its ovarian absorption rate and overall bioavailability were compared to theconventional extract. The results demonstrated a 58.5% increase in ovarian absorption when solubilized with L-Lysine. Interms of overall bioavailability, the area under the curve (AUC) value for oral administration was 3122.66 ng·hr/mL,whereas the AUC value for intravenous injection was 4191.20 ng·hr/mL. These findings suggest the potential of L-Lysinesolubilizedpaeoniflorin as an effective treatment for menopausal symptoms, offering a promising natural alternative tohormone therapy.
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KEYWORD
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L-Lysine, Menopause, Oral administration, Ovary, Paeoniflorin
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